An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet

An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet

Acetylcholinesterase (AChE) is an essential enzyme that terminates cholinergic transmission by a rapid hydrolysis of the neurotransmitter acetylcholine. AChE is an important target for treatment of various cholinergic deficiencies, including Alzheimer’s disease and myasthenia gravis. In a previous h...

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Bibliographic Details
Main Authors: Anders Allgardsson, C. David Andersson, Christine Akfur, Franz Worek, Anna Linusson, Fredrik Ekström
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Molecules
Subjects:
cholinesterase
acetylcholinesterase
cooperativity
crystal violet
Hill coefficient
new modality
non-bonded bivalence
Online Access:https://www.mdpi.com/1420-3049/22/9/1433

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