Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

Anorexigenic and Orexigenic Hormone Modulation of Mammalian Target of Rapamycin Complex 1 Activity and the Regulation of Hypothalamic Agouti-Related Protein mRNA Expression

Activation of mammalian target of rapamycin 1 (mTORC1) by nutrients, insulin and leptin leads to appetite suppression (anorexia). Contrastingly, increased AMP-activated protein kinase (AMPK) activity by ghrelin promotes appetite (orexia). However, the interplay between these mechanisms remains poorl...

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Bibliographic Details
Main Authors: Kenneth R. Watterson, Dawn Bestow, Jennifer Gallagher, D. Lee Hamilton, Fiona B. Ashford, Paul J. Meakin, Michael L.J. Ashford
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2012-03-01
Series:Neurosignals
Subjects:
Ghrelin
Leptin
Insulin
AgRP
Hypothalamus
AMP-activated protein kinase
Online Access:http://www.karger.com/Article/FullText/334144

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