Epigallocatechin-3 Gallate Inhibits <em>STAT-1/JAK2/IRF-1/HLA-DR/HLA-B</em> and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients

Epigallocatechin-3 Gallate Inhibits <em>STAT-1/JAK2/IRF-1/HLA-DR/HLA-B</em> and Reduces CD8 MKG2D Lymphocytes of Alopecia Areata Patients

Background: Alopecia areata (AA) is associated with Interferon- γ (IFN-γ) mediated T-lymphocyte dysfunction and increased circulating Interleukine-17 (IL-17) levels. Epigallocatechin-3-gallate (EGCG) specifically inhibits IFN-γ pathways and unlike Janus Kinase 1 and 2 (JAK1/JAK2) inhibitors (tofacit...

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Bibliographic Details
Main Authors: Fatma N. Hamed, Andrew J. G. McDonagh, Sarah Almaghrabi, Youssef Bakri, Andrew G. Messenger, Rachid Tazi-Ahnini
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:International Journal of Environmental Research and Public Health
Subjects:
alopecia areata
epigallocatechin-3-gallate
STAT1
CD8+ NKG2D+ subset
Online Access:https://www.mdpi.com/1660-4601/15/12/2882

Internet

https://www.mdpi.com/1660-4601/15/12/2882

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