1,25-Dihydroxyvitamin D Inhibits LPS-Induced High-Mobility Group Box 1 (HMGB1) Secretion via Targeting the NF-E2-Related Factor 2–Hemeoxygenase-1–HMGB1 Pathway in Macrophages

1,25-Dihydroxyvitamin D Inhibits LPS-Induced High-Mobility Group Box 1 (HMGB1) Secretion via Targeting the NF-E2-Related Factor 2–Hemeoxygenase-1–HMGB1 Pathway in Macrophages

1,25-Dihydroxyvitamin D [1,25(OH)2D3] is recognized as a key mediator of inflammatory diseases, including sepsis. Clinical studies demonstrate that 1,25 (OH)2D3 protects patients from sepsis, but clinical treatment with 1,25(OH)2D3 is rare. In this study, we report that 1,25(OH)2D3 treatment has ben...

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Bibliographic Details
Main Authors: Zebing Rao, Na Zhang, Ning Xu, Ying Pan, Mengjun Xiao, Junxian Wu, Hong Zhou, Shuo Yang, Yunzi Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
sepsis
vitamin D
inflammation
high-mobility group box 1 protein
damage-associated molecular patterns
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01308/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01308/full

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