PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia

PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia

Peroxisome proliferator-activated receptor γ (PPAR-γ) is a ligand-activated nuclear receptor that regulates the transcription of various genes. PPAR-γ plays roles in lipid homeostasis, sebocyte maturation, and peroxisome biogenesis and has shown anti-inflammatory effects. PPAR-γ is highly expressed...

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Main Authors: Sarawin Harnchoowong, Poonkiat Suchonwanit
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/2017/2501248
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spelling doaj-1e85aae362ec408191be5f721ba63f302020-11-24T21:09:32ZengHindawi LimitedPPAR Research1687-47571687-47652017-01-01201710.1155/2017/25012482501248PPAR-γ Agonists and Their Role in Primary Cicatricial AlopeciaSarawin Harnchoowong0Poonkiat Suchonwanit1Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandDivision of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandPeroxisome proliferator-activated receptor γ (PPAR-γ) is a ligand-activated nuclear receptor that regulates the transcription of various genes. PPAR-γ plays roles in lipid homeostasis, sebocyte maturation, and peroxisome biogenesis and has shown anti-inflammatory effects. PPAR-γ is highly expressed in human sebaceous glands. Disruption of PPAR-γ is believed to be one of the mechanisms of primary cicatricial alopecia (PCA) pathogenesis, causing pilosebaceous dysfunction leading to follicular inflammation. In this review article, we discuss the pathogenesis of PCA with a focus on PPAR-γ involvement in pathogenesis of lichen planopilaris (LPP), the most common lymphocytic form of PCA. We also discuss clinical trials utilizing PPAR-agonists in PCA treatment.http://dx.doi.org/10.1155/2017/2501248
collection DOAJ
language English
format Article
sources DOAJ
author Sarawin Harnchoowong
Poonkiat Suchonwanit
spellingShingle Sarawin Harnchoowong
Poonkiat Suchonwanit
PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia
PPAR Research
author_facet Sarawin Harnchoowong
Poonkiat Suchonwanit
author_sort Sarawin Harnchoowong
title PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia
title_short PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia
title_full PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia
title_fullStr PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia
title_full_unstemmed PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia
title_sort ppar-γ agonists and their role in primary cicatricial alopecia
publisher Hindawi Limited
series PPAR Research
issn 1687-4757
1687-4765
publishDate 2017-01-01
description Peroxisome proliferator-activated receptor γ (PPAR-γ) is a ligand-activated nuclear receptor that regulates the transcription of various genes. PPAR-γ plays roles in lipid homeostasis, sebocyte maturation, and peroxisome biogenesis and has shown anti-inflammatory effects. PPAR-γ is highly expressed in human sebaceous glands. Disruption of PPAR-γ is believed to be one of the mechanisms of primary cicatricial alopecia (PCA) pathogenesis, causing pilosebaceous dysfunction leading to follicular inflammation. In this review article, we discuss the pathogenesis of PCA with a focus on PPAR-γ involvement in pathogenesis of lichen planopilaris (LPP), the most common lymphocytic form of PCA. We also discuss clinical trials utilizing PPAR-agonists in PCA treatment.
url http://dx.doi.org/10.1155/2017/2501248
work_keys_str_mv AT sarawinharnchoowong ppargagonistsandtheirroleinprimarycicatricialalopecia
AT poonkiatsuchonwanit ppargagonistsandtheirroleinprimarycicatricialalopecia
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