Lyoprotective Effects of Mannitol and Lactose Compared to Sucrose and Trehalose: Sildenafil Citrate Liposomes as a Case Study

Lyoprotective Effects of Mannitol and Lactose Compared to Sucrose and Trehalose: Sildenafil Citrate Liposomes as a Case Study

The lyoprotective effects of mannitol and lactose have been evaluated in the production of sildenafil citrate liposomes. Liposomes were prepared by mixing the components under ultrasonic agitation, followed by a transmembrane pH gradient for remote drug loading. Mannitol and lactose, as compared to...

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Bibliographic Details
Main Authors: María José de Jesús Valle, Andreía Alves, Paula Coutinho, Maximiano Prata Ribeiro, Cristina Maderuelo, Amparo Sánchez Navarro
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceutics
Subjects:
liposomes
lyophilization
lyoprotectants
lactose
sildenafil citrate
pulmonary drug delivery
Online Access:https://www.mdpi.com/1999-4923/13/8/1164

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