Antitumor Cell-Complex Vaccines Employing Genetically Modified Tumor Cells and Fibroblasts

Antitumor Cell-Complex Vaccines Employing Genetically Modified Tumor Cells and Fibroblasts

The present study evaluates the immune response mediated by vaccination with cell complexes composed of irradiated B16 tumor cells and mouse fibroblasts genetically modified to produce GM-CSF. The animals were vaccinated with free B16 cells or cell complexes. We employed two gene plasmid constructio...

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Bibliographic Details
Main Authors: Antonio Miguel, María José Herrero, Luis Sendra, Rafael Botella, Ana Diaz, Rosa Algás, Salvador F. Aliño
Format: Article
Language:English
Published: MDPI AG 2014-02-01
Series:Toxins
Subjects:
cancer vaccines
gene therapy
non-viral
bystander cells
cell complexes
Online Access:http://www.mdpi.com/2072-6651/6/2/636

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