Deciphering the Role of B Cells in Multiple Sclerosis—Towards Specific Targeting of Pathogenic Function

Deciphering the Role of B Cells in Multiple Sclerosis—Towards Specific Targeting of Pathogenic Function

B cells, plasma cells and antibodies may play a key role in the pathogenesis of multiple sclerosis (MS). This notion is supported by various immunological changes observed in MS patients, such as activation and pro-inflammatory differentiation of peripheral blood B cells, the persistence of clonally...

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Bibliographic Details
Main Authors: Klaus Lehmann-Horn, Silke Kinzel, Martin S. Weber
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:International Journal of Molecular Sciences
Subjects:
multiple sclerosis
B cells
antibodies
antigen presenting cells
anti-CD20
plasma cells
B cell therapies
experimental autoimmune encephalomyelitis
regulatory B cells
Online Access:https://www.mdpi.com/1422-0067/18/10/2048

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