Effect of tacrolimus on the results of living related kidney donor transplantation

• Main Authors: V A Goriaĭnov, M M Kaabak, N N Babenko, M M Morozova, L I Agureeva, V V Panin, E N Platova, L I Vinnitskiĭ, N T Vorob'eva
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2014-06-01
• Series: Терапевтический архив
• Subjects: transplantation; kidney; tacrolimus; cumulative survival; immunodepression
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/31512
• ISSN: 0040-3660; 2309-5342

AIM: To elucidate whether and how tacrolimus affects the cumulative survival of patients after living related kidney donor transplantation/MATERIAL AND METHODS: The clinical materials of 246 related kidney transplant recipients, including 108 patients in whom tacrolimus (Prograf and Advagraf) Astellas Pharma US, Inc) was included in the immunodepression protocol (Group 1) and 138 patients who did not receive the agent (Group 2), were analyzed. Comparative analysis used the following tests: the Kaplan Meier test estimating the cumulative survival of recipients and transplants; the Cox test assessing the cumulative risk; and the log-rank test. Allorenal graft losses and mortality rates were also calculated./RESULTS: Mathematical analysis of the above indicators demonstrated that the allograft and survival rates were far higher (p