Design, Synthesis, Computational, and Preclinical Evaluation of <sup>nat</sup>Ti/<sup>45</sup>Ti-Labeled Urea-Based Glutamate PSMA Ligand

Design, Synthesis, Computational, and Preclinical Evaluation of <sup>nat</sup>Ti/<sup>45</sup>Ti-Labeled Urea-Based Glutamate PSMA Ligand

Despite promising anti-cancer properties in vitro, all titanium-based pharmaceuticals have failed in vivo. Likewise, no target-specific positron emission tomography (PET) tracer based on the radionuclide <sup>45</sup>Ti has been developed, notwithstanding its excellent PET imaging proper...

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Bibliographic Details
Main Authors: Kristina Søborg Pedersen, Christina Baun, Karin Michaelsen Nielsen, Helge Thisgaard, Andreas Ingemann Jensen, Fedor Zhuravlev
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Molecules
Subjects:
titanium-45
psma
pet
Online Access:https://www.mdpi.com/1420-3049/25/5/1104

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