P2.5 SEX-DEPENDENT DIFFERENCES IN OBESITY INDICES AND INFLAMMATORY MARKERS IN NON-DIABETIC OBESE PATIENTS

• Main Authors: Mariusz Stępień*, Anna Stępień, Rafał N. Wlazeł, Marek Paradowski, Maciej Banach, Jacek Rysz
• Format: Article
• Language: English
• Published: Atlantis Press 2015-11-01
• Series: Artery Research
• Online Access: https://www.atlantis-press.com/article/125930569/view

Background: The aim of the study was to asses sex-dependent differences of obesity indices and inflammatory markers in non-diabetic hypertensive obese patients. Material and methods: 40 females and 25 males aged 59.8 ±10.1 and 54.6±11.9 years, respectively, were enrolled into the study. Serum TNF-α, IL-6 and high-sensitivity C-reactive protein (hs-CRP) levels were estimated. Waist circumference (WC), waist-to-hip ratio (WHR), body mass index (BMI), waist-to-height ratio (WHtR), visceral adiposity index (VAI) and body adiposity index (BAI) were measured or calculated. Results: In males WC and WHR were higher than in females (117.0 ±10.8 cm vs 108.5 ±10.4 cm; p < 0.01 and 1.01±0.06 vs 0.91±0.06; p < 0.0001, respectively). In females BAI and hs-CRP were higher than in the males (41.7 ±6.9 vs 33.5 ±5.0; p < 0.0001 and 3.2 ±2.2 mg/l vs 2.1 ±1.5 mg/l; p < 0.05, respectively). In females hs-CRP positively correlated with WHtR (r = 0.321; p< 0.05), BMI and BAI (r = 0.305; p = 0.05, and r = 0.309; p = 0.05, respectively). In males hs-CRP positively correlated with WHtR, BAI and VAI (r= 0.458; p < 0.05; r = 0.440; p < 0.05 and r = 0.443; p < 0.05, respectively), IL-6 positively correlated with VAI (r = 0.472; p < 0.05) and TNF-α negatively correlated with WHR (r = −0.408; p < 0.05). Conclusions: Obesity related chronic inflammation is more evident in females than in males. Differences in WC, WHR and BAI are sex dependent.