Long-term and short-term immunity to SARS-CoV-2: why it matters
The adaptive immune system, regulated by CD4 T cells, is essential for control of many viral infections. Endemic coronavirus infections generally occur as short-term upper respiratory tract infections which in many cases appear to be cleared before adaptive immunity is fully involved, since adaptive...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
CSIRO Publishing
2021-01-01
|
| Series: | Microbiology Australia |
| Online Access: | https://www.publish.csiro.au/ma/pdf/MA21010 |
| id |
doaj-1e481bd5cf7b4c09b24883df4f971597 |
|---|---|
| record_format |
Article |
| spelling |
doaj-1e481bd5cf7b4c09b24883df4f9715972021-05-26T03:34:06ZengCSIRO PublishingMicrobiology Australia1324-42722201-91892021-01-014213438MA21010Long-term and short-term immunity to SARS-CoV-2: why it mattersChansavath Phetsouphanh0John Zaunders1Kirby Institute, UNSW Sydney, AustraliaCentre for Applied Medical Research, St Vincent's Hospital, Sydney, NSW, Australia; and Email: j.zaunders@amr.org.auThe adaptive immune system, regulated by CD4 T cells, is essential for control of many viral infections. Endemic coronavirus infections generally occur as short-term upper respiratory tract infections which in many cases appear to be cleared before adaptive immunity is fully involved, since adaptive immunity takes approximately 1.5–2 weeks to ramp up the response to a primary infection, or approximately 1 week for a recurrent infection. However, the adaptive immune response to SARS-CoV-2 infection will be critical to full recovery with minimal long-lasting effects, and to either prevention of recurrence of infection or at least reduced severity of symptoms. The detailed kinetics of this infection versus the dynamics of the immune response, including in vaccinated individuals, will largely determine these outcomes.https://www.publish.csiro.au/ma/pdf/MA21010 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Chansavath Phetsouphanh John Zaunders |
| spellingShingle |
Chansavath Phetsouphanh John Zaunders Long-term and short-term immunity to SARS-CoV-2: why it matters Microbiology Australia |
| author_facet |
Chansavath Phetsouphanh John Zaunders |
| author_sort |
Chansavath Phetsouphanh |
| title |
Long-term and short-term immunity to SARS-CoV-2: why it matters |
| title_short |
Long-term and short-term immunity to SARS-CoV-2: why it matters |
| title_full |
Long-term and short-term immunity to SARS-CoV-2: why it matters |
| title_fullStr |
Long-term and short-term immunity to SARS-CoV-2: why it matters |
| title_full_unstemmed |
Long-term and short-term immunity to SARS-CoV-2: why it matters |
| title_sort |
long-term and short-term immunity to sars-cov-2: why it matters |
| publisher |
CSIRO Publishing |
| series |
Microbiology Australia |
| issn |
1324-4272 2201-9189 |
| publishDate |
2021-01-01 |
| description |
The adaptive immune system, regulated by CD4 T cells, is essential for control of many viral infections. Endemic coronavirus infections generally occur as short-term upper respiratory tract infections which in many cases appear to be cleared before adaptive immunity is fully involved, since adaptive immunity takes approximately 1.5–2 weeks to ramp up the response to a primary infection, or approximately 1 week for a recurrent infection. However, the adaptive immune response to SARS-CoV-2 infection will be critical to full recovery with minimal long-lasting effects, and to either prevention of recurrence of infection or at least reduced severity of symptoms. The detailed kinetics of this infection versus the dynamics of the immune response, including in vaccinated individuals, will largely determine these outcomes. |
| url |
https://www.publish.csiro.au/ma/pdf/MA21010 |
| work_keys_str_mv |
AT chansavathphetsouphanh longtermandshorttermimmunitytosarscov2whyitmatters AT johnzaunders longtermandshorttermimmunitytosarscov2whyitmatters |
| _version_ |
1721426704255156224 |