Biomaterial-engineering and neurobiological approaches for regenerating the injured cerebral cortex
The cerebral cortex is responsible for higher functions of the central nervous system (CNS), such as movement, sensation, and cognition. When the cerebral cortex is severely injured, these functions are irreversibly impaired. Although recent neurobiological studies reveal that the cortex has the pot...
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doaj-1e442c8a8b764117af726833c22b69a72020-11-24T22:44:54ZengElsevierRegenerative Therapy2352-32042016-03-013C636710.1016/j.reth.2016.02.002Biomaterial-engineering and neurobiological approaches for regenerating the injured cerebral cortexItsuki Ajioka0Center for Brain Integration Research (CBIR), Tokyo Medical and Dental University (TMDU), Tokyo 113-8510, JapanThe cerebral cortex is responsible for higher functions of the central nervous system (CNS), such as movement, sensation, and cognition. When the cerebral cortex is severely injured, these functions are irreversibly impaired. Although recent neurobiological studies reveal that the cortex has the potential for regeneration, therapies for functional recovery face some technological obstacles. Biomaterials have been used to evoke regenerative potential and promote regeneration in several tissues, including the CNS. This review presents a brief overview of new therapeutic strategies for cortical regeneration from the perspectives of neurobiology and biomaterial engineering, and discusses a promising technology for evoking the regenerative potential of the cerebral cortex.http://www.sciencedirect.com/science/article/pii/S2352320416000158Cerebral cortexRegenerationCell cycleBiomaterials |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Itsuki Ajioka |
spellingShingle |
Itsuki Ajioka Biomaterial-engineering and neurobiological approaches for regenerating the injured cerebral cortex Regenerative Therapy Cerebral cortex Regeneration Cell cycle Biomaterials |
author_facet |
Itsuki Ajioka |
author_sort |
Itsuki Ajioka |
title |
Biomaterial-engineering and neurobiological approaches for regenerating the injured cerebral cortex |
title_short |
Biomaterial-engineering and neurobiological approaches for regenerating the injured cerebral cortex |
title_full |
Biomaterial-engineering and neurobiological approaches for regenerating the injured cerebral cortex |
title_fullStr |
Biomaterial-engineering and neurobiological approaches for regenerating the injured cerebral cortex |
title_full_unstemmed |
Biomaterial-engineering and neurobiological approaches for regenerating the injured cerebral cortex |
title_sort |
biomaterial-engineering and neurobiological approaches for regenerating the injured cerebral cortex |
publisher |
Elsevier |
series |
Regenerative Therapy |
issn |
2352-3204 |
publishDate |
2016-03-01 |
description |
The cerebral cortex is responsible for higher functions of the central nervous system (CNS), such as movement, sensation, and cognition. When the cerebral cortex is severely injured, these functions are irreversibly impaired. Although recent neurobiological studies reveal that the cortex has the potential for regeneration, therapies for functional recovery face some technological obstacles. Biomaterials have been used to evoke regenerative potential and promote regeneration in several tissues, including the CNS. This review presents a brief overview of new therapeutic strategies for cortical regeneration from the perspectives of neurobiology and biomaterial engineering, and discusses a promising technology for evoking the regenerative potential of the cerebral cortex. |
topic |
Cerebral cortex Regeneration Cell cycle Biomaterials |
url |
http://www.sciencedirect.com/science/article/pii/S2352320416000158 |
work_keys_str_mv |
AT itsukiajioka biomaterialengineeringandneurobiologicalapproachesforregeneratingtheinjuredcerebralcortex |
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1725689956759764992 |