Dopamine depletion induced up-regulation of HCN3 enhances rebound excitability of basal ganglia output neurons

Dopamine depletion induced up-regulation of HCN3 enhances rebound excitability of basal ganglia output neurons

Motor symptoms in Parkinson's disease (PD) are associated with complex changes of firing properties in basal ganglia output neurons (BGON). The abnormalities are generally attributed to altered synaptic input and potential post-synaptic mechanisms are currently unknown. Our cell-type selective...

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Bibliographic Details
Main Authors: Bernhard H. Meurers, Gustavo Dziewczapolski, Anton Bittner, Tao Shi, Fredrik Kamme, Clifford W. Shults
Format: Article
Language:English
Published: Elsevier 2009-04-01
Series:Neurobiology of Disease
Subjects:
Parkinson's disease
Basal ganglia
Entopeduncular nucleus
Microarray
HCN3
Rebound excitability
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109000096

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http://www.sciencedirect.com/science/article/pii/S0969996109000096

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