Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome.

Overexpression of Dyrk1A is implicated in several cognitive, electrophysiological and neuromorphological alterations found in a mouse model of Down syndrome.

Down syndrome (DS) phenotypes result from the overexpression of several dosage-sensitive genes. The DYRK1A (dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A) gene, which has been implicated in the behavioral and neuronal alterations that are characteristic of DS, plays a role in neu...

Full description

Bibliographic Details
Main Authors: Susana García-Cerro, Paula Martínez, Verónica Vidal, Andrea Corrales, Jesús Flórez, Rebeca Vidal, Noemí Rueda, María L Arbonés, Carmen Martínez-Cué
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4154723?pdf=render

Similar Items

Similar Items