Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study

Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study

Cinnarizine is used for the treatment of vestibular disorders. However, its poor solubility limits its clinical uses due to many challenges. Liposomes were utilised to improve the release profile of many poorly soluble drugs. However, liposomes face many stability challenges during the storage perio...

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Main Authors: Abu Abed Omar S., Mulkala Srilikha, Sharif Israa, Abdin Asma M., Elkordy Amal A.
Format: Article
Language:English
Published: De Gruyter 2021-05-01
Series:Pharmaceutical Technology in Hospital Pharmacy
Subjects:
liposomes
proliposomes
lipid delivery systems
cinnarizine
oral delivery
Online Access:https://doi.org/10.1515/pthp-2021-0002
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spelling doaj-1e386e7779cc4558bd451ea3b3f6d64d2021-10-03T07:42:43ZengDe GruyterPharmaceutical Technology in Hospital Pharmacy2365-24112365-242X2021-05-0161e1067910.1515/pthp-2021-0002Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative studyAbu Abed Omar S.0Mulkala Srilikha1Sharif Israa2Abdin Asma M.3Elkordy Amal A.4Department of Health Sciences, Arab American University, Al-Reehan, Ramallah91000, PalestineDepartment of Pharmacy and Wellbeing, University of Sunderland, Sunderland, UKDepartment of Health and Nutrition, Palestine Polytechnic University, Hebron, PalestineDepartment of Pharmacy and Wellbeing, University of Sunderland, Sunderland, UKDepartment of Pharmacy and Wellbeing, University of Sunderland, Sunderland, UKCinnarizine is used for the treatment of vestibular disorders. However, its poor solubility limits its clinical uses due to many challenges. Liposomes were utilised to improve the release profile of many poorly soluble drugs. However, liposomes face many stability challenges during the storage period. This study aims to develop proliposomes designed for the oral delivery of cinnarizine with enhanced stability characteristics.https://doi.org/10.1515/pthp-2021-0002liposomesproliposomeslipid delivery systemscinnarizineoral delivery
collection DOAJ
language English
format Article
sources DOAJ
author Abu Abed Omar S.
Mulkala Srilikha
Sharif Israa
Abdin Asma M.
Elkordy Amal A.
spellingShingle Abu Abed Omar S.
Mulkala Srilikha
Sharif Israa
Abdin Asma M.
Elkordy Amal A.
Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study
Pharmaceutical Technology in Hospital Pharmacy
liposomes
proliposomes
lipid delivery systems
cinnarizine
oral delivery
author_facet Abu Abed Omar S.
Mulkala Srilikha
Sharif Israa
Abdin Asma M.
Elkordy Amal A.
author_sort Abu Abed Omar S.
title Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study
title_short Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study
title_full Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study
title_fullStr Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study
title_full_unstemmed Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study
title_sort lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study
publisher De Gruyter
series Pharmaceutical Technology in Hospital Pharmacy
issn 2365-2411
2365-242X
publishDate 2021-05-01
description Cinnarizine is used for the treatment of vestibular disorders. However, its poor solubility limits its clinical uses due to many challenges. Liposomes were utilised to improve the release profile of many poorly soluble drugs. However, liposomes face many stability challenges during the storage period. This study aims to develop proliposomes designed for the oral delivery of cinnarizine with enhanced stability characteristics.
topic liposomes
proliposomes
lipid delivery systems
cinnarizine
oral delivery
url https://doi.org/10.1515/pthp-2021-0002
work_keys_str_mv AT abuabedomars lyophilizationfreeproliposomesforsustainedreleaseoraldeliveryofhydrophobicdrugcinnarazineacomparativestudy
AT mulkalasrilikha lyophilizationfreeproliposomesforsustainedreleaseoraldeliveryofhydrophobicdrugcinnarazineacomparativestudy
AT sharifisraa lyophilizationfreeproliposomesforsustainedreleaseoraldeliveryofhydrophobicdrugcinnarazineacomparativestudy
AT abdinasmam lyophilizationfreeproliposomesforsustainedreleaseoraldeliveryofhydrophobicdrugcinnarazineacomparativestudy
AT elkordyamala lyophilizationfreeproliposomesforsustainedreleaseoraldeliveryofhydrophobicdrugcinnarazineacomparativestudy
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