Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study

Lyophilization-free proliposomes for sustained release oral delivery of hydrophobic drug (cinnarazine): a comparative study

Cinnarizine is used for the treatment of vestibular disorders. However, its poor solubility limits its clinical uses due to many challenges. Liposomes were utilised to improve the release profile of many poorly soluble drugs. However, liposomes face many stability challenges during the storage perio...

Full description

Bibliographic Details
Main Authors: Abu Abed Omar S., Mulkala Srilikha, Sharif Israa, Abdin Asma M., Elkordy Amal A.
Format: Article
Language:English
Published: De Gruyter 2021-05-01
Series:Pharmaceutical Technology in Hospital Pharmacy
Subjects:
liposomes
proliposomes
lipid delivery systems
cinnarizine
oral delivery
Online Access:https://doi.org/10.1515/pthp-2021-0002
Description
Summary:Cinnarizine is used for the treatment of vestibular disorders. However, its poor solubility limits its clinical uses due to many challenges. Liposomes were utilised to improve the release profile of many poorly soluble drugs. However, liposomes face many stability challenges during the storage period. This study aims to develop proliposomes designed for the oral delivery of cinnarizine with enhanced stability characteristics.
ISSN:2365-2411
2365-242X

Similar Items