MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

BRCA proteins have emerged as key stabilizing factors for the maintenance of replication forks following replication stress. Here the authors describe how reversed replication forks are degraded in the absence of BRCA2, and a MUS81 and POLD3-dependent mechanism of rescue following the withdrawal of...

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Main Authors: Delphine Lemaçon, Jessica Jackson, Annabel Quinet, Joshua R. Brickner, Shan Li, Stephanie Yazinski, Zhongsheng You, Grzegorz Ira, Lee Zou, Nima Mosammaparast, Alessandro Vindigni
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01180-5
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spelling doaj-1e33c6e0d83d4e20804ca0da99f3189b2021-05-11T07:53:32ZengNature Publishing GroupNature Communications2041-17232017-10-018111210.1038/s41467-017-01180-5MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cellsDelphine Lemaçon0Jessica Jackson1Annabel Quinet2Joshua R. Brickner3Shan Li4Stephanie Yazinski5Zhongsheng You6Grzegorz Ira7Lee Zou8Nima Mosammaparast9Alessandro Vindigni10Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of MedicineEdward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of MedicineEdward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of MedicineDepartment of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of MedicineDepartment of Cell Biology and Physiology, Washington University School of MedicineMassachusetts General Hospital Cancer Center, Harvard Medical SchoolDepartment of Cell Biology and Physiology, Washington University School of MedicineDepartment of Molecular and Human Genetics, Baylor College of MedicineMassachusetts General Hospital Cancer Center, Harvard Medical SchoolDepartment of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of MedicineEdward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of MedicineBRCA proteins have emerged as key stabilizing factors for the maintenance of replication forks following replication stress. Here the authors describe how reversed replication forks are degraded in the absence of BRCA2, and a MUS81 and POLD3-dependent mechanism of rescue following the withdrawal of genotoxic agent.https://doi.org/10.1038/s41467-017-01180-5
collection DOAJ
language English
format Article
sources DOAJ
author Delphine Lemaçon
Jessica Jackson
Annabel Quinet
Joshua R. Brickner
Shan Li
Stephanie Yazinski
Zhongsheng You
Grzegorz Ira
Lee Zou
Nima Mosammaparast
Alessandro Vindigni
spellingShingle Delphine Lemaçon
Jessica Jackson
Annabel Quinet
Joshua R. Brickner
Shan Li
Stephanie Yazinski
Zhongsheng You
Grzegorz Ira
Lee Zou
Nima Mosammaparast
Alessandro Vindigni
MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
Nature Communications
author_facet Delphine Lemaçon
Jessica Jackson
Annabel Quinet
Joshua R. Brickner
Shan Li
Stephanie Yazinski
Zhongsheng You
Grzegorz Ira
Lee Zou
Nima Mosammaparast
Alessandro Vindigni
author_sort Delphine Lemaçon
title MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
title_short MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
title_full MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
title_fullStr MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
title_full_unstemmed MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
title_sort mre11 and exo1 nucleases degrade reversed forks and elicit mus81-dependent fork rescue in brca2-deficient cells
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-10-01
description BRCA proteins have emerged as key stabilizing factors for the maintenance of replication forks following replication stress. Here the authors describe how reversed replication forks are degraded in the absence of BRCA2, and a MUS81 and POLD3-dependent mechanism of rescue following the withdrawal of genotoxic agent.
url https://doi.org/10.1038/s41467-017-01180-5
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