Simultaneously imaging and quantifying in vivo mechanical properties of crystalline lens and cornea using optical coherence elastography with acoustic radiation force excitation

The crystalline lens and cornea comprise the eye’s optical system for focusing light in human vision. The changes in biomechanical properties of the lens and cornea are closely associated with common diseases, including presbyopia and cataract. Currently, most in vivo elasticity studies of the anter...

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Main Authors:	Yan Li, Jiang Zhu, Jason J. Chen, Junxiao Yu, Zi Jin, Yusi Miao, Andrew W. Browne, Qifa Zhou, Zhongping Chen
Format:	Article
Language:	English
Published:	AIP Publishing LLC 2019-10-01
Series:	APL Photonics
Online Access:	http://dx.doi.org/10.1063/1.5118258

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spelling	doaj-1e2be872488547c1a76b770e6349f45c2020-11-25T01:42:21ZengAIP Publishing LLCAPL Photonics2378-09672019-10-01410106104106104-1010.1063/1.5118258Simultaneously imaging and quantifying in vivo mechanical properties of crystalline lens and cornea using optical coherence elastography with acoustic radiation force excitationYan Li0Jiang Zhu1Jason J. Chen2Junxiao Yu3Zi Jin4Yusi Miao5Andrew W. Browne6Qifa Zhou7Zhongping Chen8Beckman Laser Institute, University of California, Irvine, Irvine, California 92612, USABeckman Laser Institute, University of California, Irvine, Irvine, California 92612, USABeckman Laser Institute, University of California, Irvine, Irvine, California 92612, USABeckman Laser Institute, University of California, Irvine, Irvine, California 92612, USABeckman Laser Institute, University of California, Irvine, Irvine, California 92612, USABeckman Laser Institute, University of California, Irvine, Irvine, California 92612, USADepartment of Biomedical Engineering, University of California, Irvine, Irvine, California 92617, USADepartment of Ophthalmology and Biomedical Engineering, University of Southern California, Los Angeles, California 90089, USABeckman Laser Institute, University of California, Irvine, Irvine, California 92612, USAThe crystalline lens and cornea comprise the eye’s optical system for focusing light in human vision. The changes in biomechanical properties of the lens and cornea are closely associated with common diseases, including presbyopia and cataract. Currently, most in vivo elasticity studies of the anterior eye focus on the measurement of the cornea, while lens measurement remains challenging. To better understand the anterior segment of the eye, we developed an optical coherence elastography system utilizing acoustic radiation force excitation to simultaneously assess the elasticities of the crystalline lens and the cornea in vivo. A swept light source was integrated into the system to provide an enhanced imaging range that covers both the lens and the cornea. Additionally, the oblique imaging approach combined with orthogonal excitation also improved the image quality. The system was tested through first ex vivo and then in vivo experiments using a rabbit model. The elasticities of corneal and lens tissue in an excised normal whole-globe and a cold cataract model were measured to reveal that cataractous lenses have a higher Young’s modulus. Simultaneous in vivo elasticity measurements of the lens and cornea were performed in a rabbit model to demonstrate the correlations between elasticity and intraocular pressure and between elasticity and age. To the best of our knowledge, we demonstrated the first in vivo elasticity of imaging of both the lens and cornea using acoustic radiation force-optical coherence elastography, thereby providing a potential powerful clinical tool to advance ophthalmic research in disorders affecting the lens and the cornea.http://dx.doi.org/10.1063/1.5118258
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yan Li Jiang Zhu Jason J. Chen Junxiao Yu Zi Jin Yusi Miao Andrew W. Browne Qifa Zhou Zhongping Chen
spellingShingle	Yan Li Jiang Zhu Jason J. Chen Junxiao Yu Zi Jin Yusi Miao Andrew W. Browne Qifa Zhou Zhongping Chen Simultaneously imaging and quantifying in vivo mechanical properties of crystalline lens and cornea using optical coherence elastography with acoustic radiation force excitation APL Photonics
author_facet	Yan Li Jiang Zhu Jason J. Chen Junxiao Yu Zi Jin Yusi Miao Andrew W. Browne Qifa Zhou Zhongping Chen
author_sort	Yan Li
title	Simultaneously imaging and quantifying in vivo mechanical properties of crystalline lens and cornea using optical coherence elastography with acoustic radiation force excitation
title_short	Simultaneously imaging and quantifying in vivo mechanical properties of crystalline lens and cornea using optical coherence elastography with acoustic radiation force excitation
title_full	Simultaneously imaging and quantifying in vivo mechanical properties of crystalline lens and cornea using optical coherence elastography with acoustic radiation force excitation
title_fullStr	Simultaneously imaging and quantifying in vivo mechanical properties of crystalline lens and cornea using optical coherence elastography with acoustic radiation force excitation
title_full_unstemmed	Simultaneously imaging and quantifying in vivo mechanical properties of crystalline lens and cornea using optical coherence elastography with acoustic radiation force excitation
title_sort	simultaneously imaging and quantifying in vivo mechanical properties of crystalline lens and cornea using optical coherence elastography with acoustic radiation force excitation
publisher	AIP Publishing LLC
series	APL Photonics
issn	2378-0967
publishDate	2019-10-01
description	The crystalline lens and cornea comprise the eye’s optical system for focusing light in human vision. The changes in biomechanical properties of the lens and cornea are closely associated with common diseases, including presbyopia and cataract. Currently, most in vivo elasticity studies of the anterior eye focus on the measurement of the cornea, while lens measurement remains challenging. To better understand the anterior segment of the eye, we developed an optical coherence elastography system utilizing acoustic radiation force excitation to simultaneously assess the elasticities of the crystalline lens and the cornea in vivo. A swept light source was integrated into the system to provide an enhanced imaging range that covers both the lens and the cornea. Additionally, the oblique imaging approach combined with orthogonal excitation also improved the image quality. The system was tested through first ex vivo and then in vivo experiments using a rabbit model. The elasticities of corneal and lens tissue in an excised normal whole-globe and a cold cataract model were measured to reveal that cataractous lenses have a higher Young’s modulus. Simultaneous in vivo elasticity measurements of the lens and cornea were performed in a rabbit model to demonstrate the correlations between elasticity and intraocular pressure and between elasticity and age. To the best of our knowledge, we demonstrated the first in vivo elasticity of imaging of both the lens and cornea using acoustic radiation force-optical coherence elastography, thereby providing a potential powerful clinical tool to advance ophthalmic research in disorders affecting the lens and the cornea.
url	http://dx.doi.org/10.1063/1.5118258
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Simultaneously imaging and quantifying in vivo mechanical properties of crystalline lens and cornea using optical coherence elastography with acoustic radiation force excitation

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