IGF-binding proteins in type 1 diabetes are more severely altered in the presence of complications

IGF-binding proteins in type 1 diabetes are more severely altered in the presence of complications

Aims: Reduced levels of free and total insulin-like growth factor 1 (IGF-I) have been observed in Type-1 Diabetes (T1D) patients. The bioavailability of IGF-I from the circulation to the target cells is controlled by multifunctional IGF binding proteins (IGFBPs). The aim of this study was to profile...

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Main Authors: Ashok eSharma, Sharad ePurohit, Shruti eSharma, Shan eBai, Wenbo eZhi, Sithara Raju ePonny, Diane eHopkins, Leigh eSteed, Bruce eBode, Stephen W Anderson, Jin-Xiong eShe
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Endocrinology
Subjects:
Diabetes Mellitus, Type 1
diabetic complications
IGF-1
IGFBP
Insulin Like Growth Factor 1
IGF binding proteins
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00002/full

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