DIAPH1 regulates chromosomal instability of cancer cells by controlling microtubule dynamics

DIAPH1 regulates chromosomal instability of cancer cells by controlling microtubule dynamics

Chromosomal instability (CIN) is a hallmark of cancer, resulting from misalignment and missegregation of chromosomes during meta- and anaphase, due to non-precise regulation of spindle-MT dynamics. Diaphanous Related Formin 1 (DIAPH1) is an actin nucleator and also binds microtubule (MT) with high a...

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Bibliographic Details
Main Authors: Shumin Miao, Paula Schäfer, Jessica Nojszewski, Felix Meyer, Sabine Windhorst
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:European Journal of Cell Biology
Subjects:
Chromosomal instability
Microtubule
Mitotic spindle
Diaphanous related formin 1
Colorectal cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S0171933521000078

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http://www.sciencedirect.com/science/article/pii/S0171933521000078

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