Relative hypoxia and oxidative stress in spleen lymphocytes of immunized Balb/c mice as indicated by HIF-1α, HIF-2α, Nrf2 expression, and glutathione peroxidase activity

Relative hypoxia and oxidative stress in spleen lymphocytes of immunized Balb/c mice as indicated by HIF-1α, HIF-2α, Nrf2 expression, and glutathione peroxidase activity

Background: Lymphocytes activated by immunization must increase their metabolism to meet the energy requirements for mitosis, differentiation, and protein synthesis, which may subject the cell to conditions of relative hypoxia and oxidative stress. This study was conducted to investigate the increas...

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Bibliographic Details
Main Authors: Citra Praditi, Ani R. Prijanti, Sri W.A. Jusman, Mohamad Sadikin
Format: Article
Language:English
Published: Faculty of Medicine Universitas Indonesia 2018-12-01
Series:Medical Journal of Indonesia
Subjects:
HIF-1α
HIF-2α
Nrf2
oxidative stress
relative hypoxia
Online Access:http://mji.ui.ac.id/journal/index.php/mji/article/view/2152

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