Hepatitis E Infection in a Renal Transplant Recipient

Hepatitis E Infection in a Renal Transplant Recipient

An asymptomatic 35-year-old renal transplant recipient was noted to have deranged liver function tests. Liver biopsy revealed a portal inflammatory process with mild lobular activity and portal fibrous expansion, consistent with a virally mediated process. An extensive viral screen confirmed infecti...

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Main Authors: Diana Vassallo, Mir Mubariz Husain, Shaun Greer, Stephen McGrath, Samreen Ijaz, Durga Kanigicherla
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Case Reports in Nephrology
Online Access:http://dx.doi.org/10.1155/2014/865471
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spelling doaj-1e139387e90c4f329592c071d2c5ab4d2020-11-24T21:05:55ZengHindawi LimitedCase Reports in Nephrology2090-66412090-665X2014-01-01201410.1155/2014/865471865471Hepatitis E Infection in a Renal Transplant RecipientDiana Vassallo0Mir Mubariz Husain1Shaun Greer2Stephen McGrath3Samreen Ijaz4Durga Kanigicherla5Department of Renal Medicine, Central Manchester NHS Foundation Trust, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UKDepartment of Clinical Virology, Central Manchester NHS Foundation Trust, Manchester M13 9WL, UKDepartment of Hepatology, Central Manchester NHS Foundation Trust, Manchester M13 9WL, UKDepartment of Pathology, Central Manchester NHS Foundation Trust, Manchester M13 9WL, UKBlood Borne Virus Unit, MS-Colindale, Public Health England, London NW9 5EQ, UKDepartment of Renal Medicine, Central Manchester NHS Foundation Trust, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UKAn asymptomatic 35-year-old renal transplant recipient was noted to have deranged liver function tests. Liver biopsy revealed a portal inflammatory process with mild lobular activity and portal fibrous expansion, consistent with a virally mediated process. An extensive viral screen confirmed infection with Hepatitis E virus genotype 3 (HEV-3). There is increased awareness about locally acquired Hepatitis E virus (HEV) infection in the transplant population in the UK. The important implications of this infection are becoming more apparent as progression to liver cirrhosis can occur. However, the incidence, natural history, and treatment of HEV infection in the transplant population are not well established. This report illustrates a case of delayed spontaneous clearance of the HEV infection.http://dx.doi.org/10.1155/2014/865471
collection DOAJ
language English
format Article
sources DOAJ
author Diana Vassallo
Mir Mubariz Husain
Shaun Greer
Stephen McGrath
Samreen Ijaz
Durga Kanigicherla
spellingShingle Diana Vassallo
Mir Mubariz Husain
Shaun Greer
Stephen McGrath
Samreen Ijaz
Durga Kanigicherla
Hepatitis E Infection in a Renal Transplant Recipient
Case Reports in Nephrology
author_facet Diana Vassallo
Mir Mubariz Husain
Shaun Greer
Stephen McGrath
Samreen Ijaz
Durga Kanigicherla
author_sort Diana Vassallo
title Hepatitis E Infection in a Renal Transplant Recipient
title_short Hepatitis E Infection in a Renal Transplant Recipient
title_full Hepatitis E Infection in a Renal Transplant Recipient
title_fullStr Hepatitis E Infection in a Renal Transplant Recipient
title_full_unstemmed Hepatitis E Infection in a Renal Transplant Recipient
title_sort hepatitis e infection in a renal transplant recipient
publisher Hindawi Limited
series Case Reports in Nephrology
issn 2090-6641
2090-665X
publishDate 2014-01-01
description An asymptomatic 35-year-old renal transplant recipient was noted to have deranged liver function tests. Liver biopsy revealed a portal inflammatory process with mild lobular activity and portal fibrous expansion, consistent with a virally mediated process. An extensive viral screen confirmed infection with Hepatitis E virus genotype 3 (HEV-3). There is increased awareness about locally acquired Hepatitis E virus (HEV) infection in the transplant population in the UK. The important implications of this infection are becoming more apparent as progression to liver cirrhosis can occur. However, the incidence, natural history, and treatment of HEV infection in the transplant population are not well established. This report illustrates a case of delayed spontaneous clearance of the HEV infection.
url http://dx.doi.org/10.1155/2014/865471
work_keys_str_mv AT dianavassallo hepatitiseinfectioninarenaltransplantrecipient
AT mirmubarizhusain hepatitiseinfectioninarenaltransplantrecipient
AT shaungreer hepatitiseinfectioninarenaltransplantrecipient
AT stephenmcgrath hepatitiseinfectioninarenaltransplantrecipient
AT samreenijaz hepatitiseinfectioninarenaltransplantrecipient
AT durgakanigicherla hepatitiseinfectioninarenaltransplantrecipient
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