Research advances in oxidative stress and mitochondrial permeability transition in liver failure

• Main Author: WANG Kefei
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Clinical Hepatology 2013-09-01
• Series: Linchuang Gandanbing Zazhi
• Subjects: liver failure; mitochondrial membranes; oxidative stress
• Online Access: http://www.lcgdbzz.org/qk_content.asp?id=5475&ClassID=8610236

Major treatment options for liver failure include clinical medical treatment, and prevention of complications), artificial liver, liver transplantation, and stem cell transplantation. While these means are known to have produced favorable outcomes, some patients died due to acute and severe onset of disease or treatment delays. Oxidative stress has emerged as a research hotspot in recent years and antioxidant treatment has been drawing increasing attention. Outlines research developments in recent years and reviews the association of oxidative stress injury and mitochondrial permeability transition pore (MPTP) with liver failure, in an effort to shed light on the importance of oxidative stress in the pathogenesis of liver failure and offer a theoretical basis and ideas for antioxidant therapy in the future.