Analysis of retinal nerve fiber layer thickness using optical coherence tomography in normal South Indian population

Introduction: The high resolution optical coherence tomography (OCT) is a new technique, which allows precise measurement of retinal thickness as well visualization of intraretinal layers, particularly the retinal nerve fiber layer (RNFL). RNFL is a very sensitive structure, which gets damaged in va...

Full description

Bibliographic Details
Main Authors: V Sowmya, V R Venkataramanan, K P Vishnu Prasad
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-01-01
Series:Muller Journal of Medical Sciences and Research
Subjects:
Online Access:http://www.mjmsr.net/article.asp?issn=0975-9727;year=2014;volume=5;issue=1;spage=5;epage=10;aulast=Sowmya
id doaj-1e1026121d1f4ff2b0ff93d6ce773b3e
record_format Article
spelling doaj-1e1026121d1f4ff2b0ff93d6ce773b3e2020-11-24T21:45:43ZengWolters Kluwer Medknow PublicationsMuller Journal of Medical Sciences and Research0975-97272014-01-015151010.4103/0975-9727.128933Analysis of retinal nerve fiber layer thickness using optical coherence tomography in normal South Indian populationV SowmyaV R VenkataramananK P Vishnu PrasadIntroduction: The high resolution optical coherence tomography (OCT) is a new technique, which allows precise measurement of retinal thickness as well visualization of intraretinal layers, particularly the retinal nerve fiber layer (RNFL). RNFL is a very sensitive structure, which gets damaged in various disease processes. Spectral domain OCT has been recently introduced in India and the normative profile of various measurements has not been established for the Indian population. Purpose of this study is to use OCT to evaluate the peripapillary variation in RNFL thickness in normal South Indian population. Materials and Methods: The study groups included 60 eyes of 30 normal individuals who underwent RNFL analysis using Topcon three-dimensional-OCT 2000. Descriptive statistical analysis has been carried out in the present study and significance was assessed at 5% level of significance. Paired t-test was used to obtain the P value. Results: In this study, average nerve fiber layer thickness along the 3.4-mm-diameter circle around the optic nerve head was 111.75 ± 4.83 μm. RNFL thickness was found to be more in the inferior quadrant followed by superior, nasal and temporal quadrant, suggesting that ISNT rule does apply to this subgroup of Indian population. Conclusion: This study concludes that RNFL thickness can be measured effectively using spectral domain OCT and should be considered while evaluating patients for diagnosis and follow-up of glaucoma. The normative data provided by this study may assist in identifying changes in RNFL thickness in glaucoma and other optic nerve diseases in South Indian population.http://www.mjmsr.net/article.asp?issn=0975-9727;year=2014;volume=5;issue=1;spage=5;epage=10;aulast=SowmyaOptic nerve diseasesoptical coherence tomographyretinal nerve fiber layerSouth Indian population
collection DOAJ
language English
format Article
sources DOAJ
author V Sowmya
V R Venkataramanan
K P Vishnu Prasad
spellingShingle V Sowmya
V R Venkataramanan
K P Vishnu Prasad
Analysis of retinal nerve fiber layer thickness using optical coherence tomography in normal South Indian population
Muller Journal of Medical Sciences and Research
Optic nerve diseases
optical coherence tomography
retinal nerve fiber layer
South Indian population
author_facet V Sowmya
V R Venkataramanan
K P Vishnu Prasad
author_sort V Sowmya
title Analysis of retinal nerve fiber layer thickness using optical coherence tomography in normal South Indian population
title_short Analysis of retinal nerve fiber layer thickness using optical coherence tomography in normal South Indian population
title_full Analysis of retinal nerve fiber layer thickness using optical coherence tomography in normal South Indian population
title_fullStr Analysis of retinal nerve fiber layer thickness using optical coherence tomography in normal South Indian population
title_full_unstemmed Analysis of retinal nerve fiber layer thickness using optical coherence tomography in normal South Indian population
title_sort analysis of retinal nerve fiber layer thickness using optical coherence tomography in normal south indian population
publisher Wolters Kluwer Medknow Publications
series Muller Journal of Medical Sciences and Research
issn 0975-9727
publishDate 2014-01-01
description Introduction: The high resolution optical coherence tomography (OCT) is a new technique, which allows precise measurement of retinal thickness as well visualization of intraretinal layers, particularly the retinal nerve fiber layer (RNFL). RNFL is a very sensitive structure, which gets damaged in various disease processes. Spectral domain OCT has been recently introduced in India and the normative profile of various measurements has not been established for the Indian population. Purpose of this study is to use OCT to evaluate the peripapillary variation in RNFL thickness in normal South Indian population. Materials and Methods: The study groups included 60 eyes of 30 normal individuals who underwent RNFL analysis using Topcon three-dimensional-OCT 2000. Descriptive statistical analysis has been carried out in the present study and significance was assessed at 5% level of significance. Paired t-test was used to obtain the P value. Results: In this study, average nerve fiber layer thickness along the 3.4-mm-diameter circle around the optic nerve head was 111.75 ± 4.83 μm. RNFL thickness was found to be more in the inferior quadrant followed by superior, nasal and temporal quadrant, suggesting that ISNT rule does apply to this subgroup of Indian population. Conclusion: This study concludes that RNFL thickness can be measured effectively using spectral domain OCT and should be considered while evaluating patients for diagnosis and follow-up of glaucoma. The normative data provided by this study may assist in identifying changes in RNFL thickness in glaucoma and other optic nerve diseases in South Indian population.
topic Optic nerve diseases
optical coherence tomography
retinal nerve fiber layer
South Indian population
url http://www.mjmsr.net/article.asp?issn=0975-9727;year=2014;volume=5;issue=1;spage=5;epage=10;aulast=Sowmya
work_keys_str_mv AT vsowmya analysisofretinalnervefiberlayerthicknessusingopticalcoherencetomographyinnormalsouthindianpopulation
AT vrvenkataramanan analysisofretinalnervefiberlayerthicknessusingopticalcoherencetomographyinnormalsouthindianpopulation
AT kpvishnuprasad analysisofretinalnervefiberlayerthicknessusingopticalcoherencetomographyinnormalsouthindianpopulation
_version_ 1725904764631252992