Role of bone morphogenetic protein-7/Smads signaling pathway in hepatic fibrosis

Role of bone morphogenetic protein-7/Smads signaling pathway in hepatic fibrosis

Hepatic fibrosis is the process in which the human body repairs the liver tissue damaged due to various reasons. Recent studies have found that bone morphogenetic protein-7 (BMP-7) and the downstream Smads can antagonize the effect of transforming growth factor-β1, which induces hepatic fibrosis, th...

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Main Authors: HOU Fei, LIU Ruixia, YIN Chenghong
Format: Article
Language:zho
Published: Editorial Department of Journal of Clinical Hepatology 2016-05-01
Series:Linchuang Gandanbing Zazhi
Online Access:http://www.lcgdbzz.org/qk_content.asp?id=7426
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spelling doaj-1e0fde24f62640b48622f7a7c7633f672020-11-24T23:23:19ZzhoEditorial Department of Journal of Clinical HepatologyLinchuang Gandanbing Zazhi1001-52561001-52562016-05-013251001100410.3969/j.issn.1001-5256.2016.05.046Role of bone morphogenetic protein-7/Smads signaling pathway in hepatic fibrosisHOU Fei0LIU Ruixia1YIN Chenghong2Department of Infection, Beijing Friendship Haspital, Capital Medical University, Beijing 100050, ChinaDepartment of Infection, Beijing Friendship Haspital, Capital Medical University, Beijing 100050, ChinaDepartment of Infection, Beijing Friendship Haspital, Capital Medical University, Beijing 100050, ChinaHepatic fibrosis is the process in which the human body repairs the liver tissue damaged due to various reasons. Recent studies have found that bone morphogenetic protein-7 (BMP-7) and the downstream Smads can antagonize the effect of transforming growth factor-β1, which induces hepatic fibrosis, through various pathways, including inducing the degradation of extracellular matrix, inhibiting cell apoptosis, reducing the expression of various proinflammatory factors, and promoting the regeneration of hepatocytes. This article investigates the role of BMP-7/Smads signaling pathway in hepatic fibrosis.http://www.lcgdbzz.org/qk_content.asp?id=7426
collection DOAJ
language zho
format Article
sources DOAJ
author HOU Fei
LIU Ruixia
YIN Chenghong
spellingShingle HOU Fei
LIU Ruixia
YIN Chenghong
Role of bone morphogenetic protein-7/Smads signaling pathway in hepatic fibrosis
Linchuang Gandanbing Zazhi
author_facet HOU Fei
LIU Ruixia
YIN Chenghong
author_sort HOU Fei
title Role of bone morphogenetic protein-7/Smads signaling pathway in hepatic fibrosis
title_short Role of bone morphogenetic protein-7/Smads signaling pathway in hepatic fibrosis
title_full Role of bone morphogenetic protein-7/Smads signaling pathway in hepatic fibrosis
title_fullStr Role of bone morphogenetic protein-7/Smads signaling pathway in hepatic fibrosis
title_full_unstemmed Role of bone morphogenetic protein-7/Smads signaling pathway in hepatic fibrosis
title_sort role of bone morphogenetic protein-7/smads signaling pathway in hepatic fibrosis
publisher Editorial Department of Journal of Clinical Hepatology
series Linchuang Gandanbing Zazhi
issn 1001-5256
1001-5256
publishDate 2016-05-01
description Hepatic fibrosis is the process in which the human body repairs the liver tissue damaged due to various reasons. Recent studies have found that bone morphogenetic protein-7 (BMP-7) and the downstream Smads can antagonize the effect of transforming growth factor-β1, which induces hepatic fibrosis, through various pathways, including inducing the degradation of extracellular matrix, inhibiting cell apoptosis, reducing the expression of various proinflammatory factors, and promoting the regeneration of hepatocytes. This article investigates the role of BMP-7/Smads signaling pathway in hepatic fibrosis.
url http://www.lcgdbzz.org/qk_content.asp?id=7426
work_keys_str_mv AT houfei roleofbonemorphogeneticprotein7smadssignalingpathwayinhepaticfibrosis
AT liuruixia roleofbonemorphogeneticprotein7smadssignalingpathwayinhepaticfibrosis
AT yinchenghong roleofbonemorphogeneticprotein7smadssignalingpathwayinhepaticfibrosis
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