In Ovarian Cancer Multicellular Spheroids, Platelet Releasate Promotes Growth, Expansion of ALDH+ and CD133+ Cancer Stem Cells, and Protection against the Cytotoxic Effects of Cisplatin, Carboplatin and Paclitaxel

In Ovarian Cancer Multicellular Spheroids, Platelet Releasate Promotes Growth, Expansion of ALDH+ and CD133+ Cancer Stem Cells, and Protection against the Cytotoxic Effects of Cisplatin, Carboplatin and Paclitaxel

A high platelet count is associated with a poor prognosis in ovarian cancer (OvCa). Despite good clinical responses with platinating agents in combination with taxanes, numerous OvCa patients relapse due to chemotherapy resistance. Here, we report that treatment of OvCa cells A2780, OVCAR5 and MDAH...

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Bibliographic Details
Main Authors: Naike Casagrande, Cinzia Borghese, Francesco Agostini, Cristina Durante, Mario Mazzucato, Alfonso Colombatti, Donatella Aldinucci
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
platelet releasate
ovarian cancer stem cells
ovarian cancer spheroids
anticancer therapy
drug resistance
cisplatin
Online Access:https://www.mdpi.com/1422-0067/22/6/3019

Internet

https://www.mdpi.com/1422-0067/22/6/3019

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