LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

Chromosome segregation and genome maintenance require the removal of DNA bridges that link chromosomes just before cells divide. Here the authors show that the LEM-3/Ankle1 nuclease processes DNA bridges before cells divide and define a previously undescribed genome integrity mechanism.

Bibliographic Details
Main Authors:	Ye Hong, Remi Sonneville, Bin Wang, Viktor Scheidt, Bettina Meier, Alexander Woglar, Sarah Demetriou, Karim Labib, Verena Jantsch, Anton Gartner
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-03135-w

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spelling	doaj-1e006c13ac23401faf2de36c69fca25c2021-05-11T09:25:17ZengNature Publishing GroupNature Communications2041-17232018-02-019111110.1038/s41467-018-03135-wLEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosisYe Hong0Remi Sonneville1Bin Wang2Viktor Scheidt3Bettina Meier4Alexander Woglar5Sarah Demetriou6Karim Labib7Verena Jantsch8Anton Gartner9Centre for Gene Regulation and Expression, School of Life Sciences, University of DundeeMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of DundeeCentre for Gene Regulation and Expression, School of Life Sciences, University of DundeeCentre for Gene Regulation and Expression, School of Life Sciences, University of DundeeCentre for Gene Regulation and Expression, School of Life Sciences, University of DundeeDepartment of Chromosome Biology, Max F. Perutz Laboratories, Vienna Biocenter, University of ViennaCentre for Gene Regulation and Expression, School of Life Sciences, University of DundeeMRC Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of DundeeDepartment of Chromosome Biology, Max F. Perutz Laboratories, Vienna Biocenter, University of ViennaCentre for Gene Regulation and Expression, School of Life Sciences, University of DundeeChromosome segregation and genome maintenance require the removal of DNA bridges that link chromosomes just before cells divide. Here the authors show that the LEM-3/Ankle1 nuclease processes DNA bridges before cells divide and define a previously undescribed genome integrity mechanism.https://doi.org/10.1038/s41467-018-03135-w
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ye Hong Remi Sonneville Bin Wang Viktor Scheidt Bettina Meier Alexander Woglar Sarah Demetriou Karim Labib Verena Jantsch Anton Gartner
spellingShingle	Ye Hong Remi Sonneville Bin Wang Viktor Scheidt Bettina Meier Alexander Woglar Sarah Demetriou Karim Labib Verena Jantsch Anton Gartner LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis Nature Communications
author_facet	Ye Hong Remi Sonneville Bin Wang Viktor Scheidt Bettina Meier Alexander Woglar Sarah Demetriou Karim Labib Verena Jantsch Anton Gartner
author_sort	Ye Hong
title	LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis
title_short	LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis
title_full	LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis
title_fullStr	LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis
title_full_unstemmed	LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis
title_sort	lem-3 is a midbody-tethered dna nuclease that resolves chromatin bridges during late mitosis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-02-01
description	Chromosome segregation and genome maintenance require the removal of DNA bridges that link chromosomes just before cells divide. Here the authors show that the LEM-3/Ankle1 nuclease processes DNA bridges before cells divide and define a previously undescribed genome integrity mechanism.
url	https://doi.org/10.1038/s41467-018-03135-w
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LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

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