Silencing of Poly(ADP-Ribose) Polymerase-2 Induces Mitochondrial Reactive Species Production and Mitochondrial Fragmentation

Silencing of Poly(ADP-Ribose) Polymerase-2 Induces Mitochondrial Reactive Species Production and Mitochondrial Fragmentation

PARP2 is a DNA repair protein. The deletion of PARP2 induces mitochondrial biogenesis and mitochondrial activity by increasing NAD<sup>+</sup> levels and inducing SIRT1 activity. We show that the silencing of PARP2 causes mitochondrial fragmentation in myoblasts. We assessed multiple pat...

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Bibliographic Details
Main Authors: Laura Jankó, Tünde Kovács, Miklós Laczik, Zsanett Sári, Gyula Ujlaki, Gréta Kis, Ibolya Horváth, Miklós Antal, László Vígh, Bálint L. Bálint, Karen Uray, Péter Bai
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cells
Subjects:
PARP2
ARTD2
oxidative stress
mitochondrial biogenesis
skeletal muscle
mitochondrial fragmentation
Online Access:https://www.mdpi.com/2073-4409/10/6/1387

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