Application of tumor necrosis factor antagonists in hepatic disease treatment

Application of tumor necrosis factor antagonists in hepatic disease treatment

All tumor necrosis factor (TNF) antagonists are associated with hepatotoxicity and thus induce liver injury, commonly manifested as hepatitis B virus and hepatitis C virus reactivation, acute hepatitis, drug-induced liver disease, cholestasis, serum liver enzyme activity elevation, and even acute li...

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Main Authors: CHI Zhaochun, GENG Changxin
Format: Article
Language:zho
Published: Editorial Department of Journal of Clinical Hepatology 2015-07-01
Series:Linchuang Gandanbing Zazhi
Online Access:http://www.lcgdbzz.org/qk_content.asp?id=6666
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spelling doaj-1df9ec2176944ab1ab7f20689d45f60d2020-11-24T23:30:19ZzhoEditorial Department of Journal of Clinical HepatologyLinchuang Gandanbing Zazhi1001-52561001-52562015-07-013171176117810.3969/j.issn.1001-5256.2015.07.045Application of tumor necrosis factor antagonists in hepatic disease treatmentCHI Zhaochun0GENG Changxin1Department of Gastroenterology, Qingdao Municipal Hospital, Affiliated Hospital of College of Pharmacy, Ocean University of China, Qingdao, Shandong 266071, ChinaDepartment of Gastroenterology, Qingdao Municipal Hospital, Affiliated Hospital of College of Pharmacy, Ocean University of China, Qingdao, Shandong 266071, ChinaAll tumor necrosis factor (TNF) antagonists are associated with hepatotoxicity and thus induce liver injury, commonly manifested as hepatitis B virus and hepatitis C virus reactivation, acute hepatitis, drug-induced liver disease, cholestasis, serum liver enzyme activity elevation, and even acute liver failure. Hence, the application of TNF antagonists in hepatic disease treatment remains controversial. This review summarizes currently available data on the mechanism and application of TNF antagonists in hepatic disease treatment. Although TNF antagonists have been applied for many years, large randomized controlled trials are still recommended to assess its efficacy and safety and to achieve a consensus.http://www.lcgdbzz.org/qk_content.asp?id=6666
collection DOAJ
language zho
format Article
sources DOAJ
author CHI Zhaochun
GENG Changxin
spellingShingle CHI Zhaochun
GENG Changxin
Application of tumor necrosis factor antagonists in hepatic disease treatment
Linchuang Gandanbing Zazhi
author_facet CHI Zhaochun
GENG Changxin
author_sort CHI Zhaochun
title Application of tumor necrosis factor antagonists in hepatic disease treatment
title_short Application of tumor necrosis factor antagonists in hepatic disease treatment
title_full Application of tumor necrosis factor antagonists in hepatic disease treatment
title_fullStr Application of tumor necrosis factor antagonists in hepatic disease treatment
title_full_unstemmed Application of tumor necrosis factor antagonists in hepatic disease treatment
title_sort application of tumor necrosis factor antagonists in hepatic disease treatment
publisher Editorial Department of Journal of Clinical Hepatology
series Linchuang Gandanbing Zazhi
issn 1001-5256
1001-5256
publishDate 2015-07-01
description All tumor necrosis factor (TNF) antagonists are associated with hepatotoxicity and thus induce liver injury, commonly manifested as hepatitis B virus and hepatitis C virus reactivation, acute hepatitis, drug-induced liver disease, cholestasis, serum liver enzyme activity elevation, and even acute liver failure. Hence, the application of TNF antagonists in hepatic disease treatment remains controversial. This review summarizes currently available data on the mechanism and application of TNF antagonists in hepatic disease treatment. Although TNF antagonists have been applied for many years, large randomized controlled trials are still recommended to assess its efficacy and safety and to achieve a consensus.
url http://www.lcgdbzz.org/qk_content.asp?id=6666
work_keys_str_mv AT chizhaochun applicationoftumornecrosisfactorantagonistsinhepaticdiseasetreatment
AT gengchangxin applicationoftumornecrosisfactorantagonistsinhepaticdiseasetreatment
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