Prolonged exposure of colon cancer cells to 5-fluorouracil nanoparticles improves its anticancer activity

Prolonged exposure of colon cancer cells to 5-fluorouracil nanoparticles improves its anticancer activity

In this study, we aimed to improve the anticancer effect of 5-FU on human colon cancer cell lines by incorporating in poly(d,l lactic-co-glycolic acid) (PLGA) nanoparticles (NPs). The 5-FU-PLGA NPs were prepared by nanoprecipitation technique. Prepared NPs were moderately dispersed with an average d...

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Bibliographic Details
Main Authors: Essam Tawfik, Maqusood Ahamed, Abdulaziz Almalik, Mohammad Alfaqeeh, Aws Alshamsan
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Saudi Pharmaceutical Journal
Subjects:
5-Fluorouracil
Nanoparticles
Colon cancer
PLGA
Drug delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S1319016416300585

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