Common mechanism of transcription termination at coding and noncoding RNA genes in fission yeast

Common mechanism of transcription termination at coding and noncoding RNA genes in fission yeast

Termination of RNA polymerase II (RNAPII) transcription is an essential step of gene expression. Here the authors provide evidence that in fission yeast termination of ncRNA genes occurs by a cleavage-dependent mechanism involving recruitment of mRNA 3′ end processing factors and requires the conser...

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Bibliographic Details
Main Authors: Marc Larochelle, Marc-Antoine Robert, Jean-Nicolas Hébert, Xiaochuan Liu, Dominick Matteau, Sébastien Rodrigue, Bin Tian, Pierre-Étienne Jacques, François Bachand
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06546-x
Description
Summary:Termination of RNA polymerase II (RNAPII) transcription is an essential step of gene expression. Here the authors provide evidence that in fission yeast termination of ncRNA genes occurs by a cleavage-dependent mechanism involving recruitment of mRNA 3′ end processing factors and requires the conserved Ysh1/CPSF-73 and Dhp1/XRN2 nucleases.
ISSN:2041-1723

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