New methods of prevention and treatment of acute respiratory viral infections in children. Local protection factors of the respiratory mucosa

• Main Authors: N. A. Geppe, I. V. Oserskaya, N. G. Kolosova
• Format: Article
• Language: Russian
• Published: Ltd. “The National Academy of Pediatric Science and Innovation” 2019-11-01
• Series: Rossijskij Vestnik Perinatologii i Pediatrii
• Subjects: children; arvi; nasal mucosa; local protective factors; saline solutions
• Online Access: https://www.ped-perinatology.ru/jour/article/view/964
• ISSN: 1027-4065; 2500-2228

Acute respiratory viral infections (ARVI) are the most common diseases among children. The typical and most disturbing symptoms of ARVI are nasal discharge, nasal congestion and difficulty in nasal breathing. Local protective factors of the respiratory mucosa (epithelial barrier, mucociliary clearance, antimicrobial peptides, immunoglobulin A, microbiota) prevent the penetration of respiratory infections. To prevent ARVI in children it is important to maintain the physiological state of the mucous membrane. ARVI treatment in children is based on care and supportive activities. By irrigating nasal cavity with saline one removes mucus, mechanical impurities, stimulates mucociliary clearance, reduces swelling of the mucous membrane and need for decongestants. The new nasal spray Aqualor Protect contains 45% of sea water with a slightly hypertonic concentration of salts (1.5%) and Ascophillum nodosum brown algae extract. The main polysaccharides of brown algae - fucoidan and ascofillan - have a wide range of biological actions, including anti-inflammatory and antiviral properties. The extract of brown algae added to saline helps to increase the effectiveness of irrigation therapy in the treatment and prevention of acute respiratory viral infections in children.