SNARE Zippering Is Suppressed by a Conformational Constraint that Is Removed by v-SNARE Splitting

SNARE Zippering Is Suppressed by a Conformational Constraint that Is Removed by v-SNARE Splitting

Summary: Intracellular vesicle fusion is catalyzed by soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). Vesicle-anchored v-SNAREs pair with target membrane-associated t-SNAREs to form trans-SNARE complexes, releasing free energy to drive membrane fusion. However, trans...

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Bibliographic Details
Main Authors: Yinghui Liu, Chun Wan, Shailendra S. Rathore, Michael H.B. Stowell, Haijia Yu, Jingshi Shen
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Cell Reports
Subjects:
SNARE
SM protein
membrane fusion
vesicle fusion
vesicle fusion specificity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720316004

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