RNA Editing and Drug Discovery for Cancer Therapy

RNA editing is vital to provide the RNA and protein complexity to regulate the gene expression. Correct RNA editing maintains the cell function and organism development. Imbalance of the RNA editing machinery may lead to diseases and cancers. Recently, RNA editing has been recognized as a target for...

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Main Authors:	Wei-Hsuan Huang, Chao-Neng Tseng, Jen-Yang Tang, Cheng-Hong Yang, Shih-Shin Liang, Hsueh-Wei Chang
Format:	Article
Language:	English
Published:	Hindawi Limited 2013-01-01
Series:	The Scientific World Journal
Online Access:	http://dx.doi.org/10.1155/2013/804505

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spelling	doaj-1dd403c32b3c4ac791a0a639938a1ed42020-11-24T22:08:23ZengHindawi LimitedThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/804505804505RNA Editing and Drug Discovery for Cancer TherapyWei-Hsuan Huang0Chao-Neng Tseng1Jen-Yang Tang2Cheng-Hong Yang3Shih-Shin Liang4Hsueh-Wei Chang5Department of Pharmacy, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, TaiwanGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Radiation Oncology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Electronic Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung 807, TaiwanDepartment of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, TaiwanGraduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, TaiwanRNA editing is vital to provide the RNA and protein complexity to regulate the gene expression. Correct RNA editing maintains the cell function and organism development. Imbalance of the RNA editing machinery may lead to diseases and cancers. Recently, RNA editing has been recognized as a target for drug discovery although few studies targeting RNA editing for disease and cancer therapy were reported in the field of natural products. Therefore, RNA editing may be a potential target for therapeutic natural products. In this review, we provide a literature overview of the biological functions of RNA editing on gene expression, diseases, cancers, and drugs. The bioinformatics resources of RNA editing were also summarized.http://dx.doi.org/10.1155/2013/804505
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Wei-Hsuan Huang Chao-Neng Tseng Jen-Yang Tang Cheng-Hong Yang Shih-Shin Liang Hsueh-Wei Chang
spellingShingle	Wei-Hsuan Huang Chao-Neng Tseng Jen-Yang Tang Cheng-Hong Yang Shih-Shin Liang Hsueh-Wei Chang RNA Editing and Drug Discovery for Cancer Therapy The Scientific World Journal
author_facet	Wei-Hsuan Huang Chao-Neng Tseng Jen-Yang Tang Cheng-Hong Yang Shih-Shin Liang Hsueh-Wei Chang
author_sort	Wei-Hsuan Huang
title	RNA Editing and Drug Discovery for Cancer Therapy
title_short	RNA Editing and Drug Discovery for Cancer Therapy
title_full	RNA Editing and Drug Discovery for Cancer Therapy
title_fullStr	RNA Editing and Drug Discovery for Cancer Therapy
title_full_unstemmed	RNA Editing and Drug Discovery for Cancer Therapy
title_sort	rna editing and drug discovery for cancer therapy
publisher	Hindawi Limited
series	The Scientific World Journal
issn	1537-744X
publishDate	2013-01-01
description	RNA editing is vital to provide the RNA and protein complexity to regulate the gene expression. Correct RNA editing maintains the cell function and organism development. Imbalance of the RNA editing machinery may lead to diseases and cancers. Recently, RNA editing has been recognized as a target for drug discovery although few studies targeting RNA editing for disease and cancer therapy were reported in the field of natural products. Therefore, RNA editing may be a potential target for therapeutic natural products. In this review, we provide a literature overview of the biological functions of RNA editing on gene expression, diseases, cancers, and drugs. The bioinformatics resources of RNA editing were also summarized.
url	http://dx.doi.org/10.1155/2013/804505
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RNA Editing and Drug Discovery for Cancer Therapy

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