Oral versus intravenous antibiotics for bone and joint infections: the OVIVA non-inferiority RCT

Oral versus intravenous antibiotics for bone and joint infections: the OVIVA non-inferiority RCT

Background: Management of bone and joint infection commonly includes 4–6 weeks of intravenous (IV) antibiotics, but there is little evidence to suggest that oral (PO) therapy results in worse outcomes. Objective: To determine whether or not PO antibiotics are non-inferior to IV antibiotics in treati...

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Bibliographic Details
Main Authors: Matthew Scarborough, Ho Kwong Li, Ines Rombach, Rhea Zambellas, A Sarah Walker, Martin McNally, Bridget Atkins, Michelle Kümin, Benjamin A Lipsky, Harriet Hughes, Deepa Bose, Simon Warren, Damien Mack, Jonathan Folb, Elinor Moore, Neil Jenkins, Susan Hopkins, R Andrew Seaton, Carolyn Hemsley, Jonathan Sandoe, Ila Aggarwal, Simon Ellis, Rebecca Sutherland, Claudia Geue, Nicola McMeekin, Claire Scarborough, John Paul, Graham Cooke, Jennifer Bostock, Elham Khatamzas, Nick Wong, Andrew Brent, Jose Lomas, Philippa Matthews, Tri Wangrangsimakul, Roger Gundle, Mark Rogers, Adrian Taylor, Guy E Thwaites, Philip Bejon
Format: Article
Language:English
Published: NIHR Journals Library 2019-08-01
Series:Health Technology Assessment
Subjects:
BONE AND JOINT INFECTION
ORAL
INTRAVENOUS
ANTIBIOTIC
NON-INFERIORITY
RANDOMISED CONTROLLED TRIAL
TREATMENT FAILURE
Online Access:https://doi.org/10.3310/hta23380

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