| Summary: | <p><emph>Background.</emph> The aim of this study is to assess the impacts of “<emph>Maras powder</emph>” and cigarette smoking on the parameters of the humoral immune system. <emph>Material and Methods.</emph> One hundred seventy seven subjects were included in the study. The IgA, IgG, IgM, C3 and C4 levels were detected via nephelometric method. <emph>Results</emph>. In 1.4 % of the control group IgM levels were below normal where it was 10.8 % and 18.6 % in Maras powder group and in cigarette smoking group respectively. The IgM levels of both groups were significantly lower compared to the control group (P<.05). Nonetheless, the IgE levels of Maras powder group and smoking group were found to be remarkably higher compared to the control group (P<.01). <emph>Conclusion.</emph> Effects of <emph>Maras powder</emph> on humoral immune response were found to be similar to that of smoking.</p>
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