Heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactions

Heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactions

Cells contain isolated compartments where cascade enzymatic biochemical reactions occur to form essential biological products with high efficiency. Here the authors produce functional hydrogel particles with multiple compartments via microfluidics that contain spatially immobilized natural enzymes i...

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Bibliographic Details
Main Authors: Hongliang Tan, Song Guo, Ngoc-Duy Dinh, Rongcong Luo, Lin Jin, Chia-Hung Chen
Format: Article
Language:English
Published: Nature Publishing Group 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00757-4
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spelling doaj-1daf49c724184f3aac023a53cb359ed82021-05-11T07:42:45ZengNature Publishing GroupNature Communications2041-17232017-09-018111010.1038/s41467-017-00757-4Heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactionsHongliang Tan0Song Guo1Ngoc-Duy Dinh2Rongcong Luo3Lin Jin4Chia-Hung Chen5Department of Biomedical Engineering, National University of SingaporeDepartment of Biomedical Engineering, National University of SingaporeDepartment of Biomedical Engineering, National University of SingaporeDepartment of Biomedical Engineering, National University of SingaporeDepartment of Biomedical Engineering, National University of SingaporeDepartment of Biomedical Engineering, National University of SingaporeCells contain isolated compartments where cascade enzymatic biochemical reactions occur to form essential biological products with high efficiency. Here the authors produce functional hydrogel particles with multiple compartments via microfluidics that contain spatially immobilized natural enzymes in distinct domains for one-pot, tandem reactions.https://doi.org/10.1038/s41467-017-00757-4
collection DOAJ
language English
format Article
sources DOAJ
author Hongliang Tan
Song Guo
Ngoc-Duy Dinh
Rongcong Luo
Lin Jin
Chia-Hung Chen
spellingShingle Hongliang Tan
Song Guo
Ngoc-Duy Dinh
Rongcong Luo
Lin Jin
Chia-Hung Chen
Heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactions
Nature Communications
author_facet Hongliang Tan
Song Guo
Ngoc-Duy Dinh
Rongcong Luo
Lin Jin
Chia-Hung Chen
author_sort Hongliang Tan
title Heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactions
title_short Heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactions
title_full Heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactions
title_fullStr Heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactions
title_full_unstemmed Heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactions
title_sort heterogeneous multi-compartmental hydrogel particles as synthetic cells for incompatible tandem reactions
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-09-01
description Cells contain isolated compartments where cascade enzymatic biochemical reactions occur to form essential biological products with high efficiency. Here the authors produce functional hydrogel particles with multiple compartments via microfluidics that contain spatially immobilized natural enzymes in distinct domains for one-pot, tandem reactions.
url https://doi.org/10.1038/s41467-017-00757-4
work_keys_str_mv AT hongliangtan heterogeneousmulticompartmentalhydrogelparticlesassyntheticcellsforincompatibletandemreactions
AT songguo heterogeneousmulticompartmentalhydrogelparticlesassyntheticcellsforincompatibletandemreactions
AT ngocduydinh heterogeneousmulticompartmentalhydrogelparticlesassyntheticcellsforincompatibletandemreactions
AT rongcongluo heterogeneousmulticompartmentalhydrogelparticlesassyntheticcellsforincompatibletandemreactions
AT linjin heterogeneousmulticompartmentalhydrogelparticlesassyntheticcellsforincompatibletandemreactions
AT chiahungchen heterogeneousmulticompartmentalhydrogelparticlesassyntheticcellsforincompatibletandemreactions
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