Chemokine, vascular and therapeutic effects of combination Simvastatin and BMSC treatment of stroke

We investigated the additive therapeutic effect of the combination treatment of stroke with sub-therapeutic doses of Simvastatin, a HMG-CoA reductase inhibitor, and bone marrow stromal cells (BMSCs). Rats were administered Simvastatin (0.5 mg/kg), BMSCs (1×106) or combination of Simvastatin and BMSC...

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Bibliographic Details
Main Authors: Xu Cui, Michael Chopp, Alex Zacharek, Cynthia Roberts, Mei Lu, Smita Savant-Bhonsale, Jieli Chen
Format: Article
Language:English
Published: Elsevier 2009-10-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109001612