PM2.5 exposure aggravates oligomeric amyloid beta-induced neuronal injury and promotes NLRP3 inflammasome activation in an in vitro model of Alzheimer’s disease

PM2.5 exposure aggravates oligomeric amyloid beta-induced neuronal injury and promotes NLRP3 inflammasome activation in an in vitro model of Alzheimer’s disease

Abstract Background Numerous studies suggested that PM2.5 exposure was associated with increased risk of Alzheimer’s disease (AD). But the precise mechanisms by which PM2.5 contributed to AD pathogenesis have not been clarified. Methods In the presence or absence of neurons, oligomeric amyloid beta...

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Bibliographic Details
Main Authors: Bian-Rong Wang, Jian-Quan Shi, Nian-Nian Ge, Zhou Ou, You-Yong Tian, Teng Jiang, Jun-Shan Zhou, Jun Xu, Ying-Dong Zhang
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
PM2.5
Neuronal injury
Inflammation
NLRP3 inflammasome
ROS
Online Access:http://link.springer.com/article/10.1186/s12974-018-1178-5

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