A Novel Graphic-Aided Algorithm (gNIPT) Improves the Accuracy of Noninvasive Prenatal Testing

Noninvasive Prenatal Testing (NIPT) has advanced the detection of fetal chromosomal aneuploidy by analyzing cell-free DNA in peripheral maternal blood. The statistic Z-test that it utilizes, which measures the deviation of each chromosome dosage from its negative control, is now widely accepted in c...

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Bibliographic Details
Main Authors: Qingwen Zhu, Jing Wang, Xiaoning Xu, Shiying Zhou, Zhengli Liao, Jun Zhang, Lingyin Kong, Bo Liang, Xiaoyan Cheng
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2020/4712657