Gene Therapy in Mouse Models of Deafness and Balance Dysfunction

Gene Therapy in Mouse Models of Deafness and Balance Dysfunction

Therapeutic strategies to restore hearing and balance in mouse models of inner ear disease aim to rescue sensory function by gene replacement, augmentation, knock down or knock out. Modalities to achieve therapeutic effects have utilized virus-mediated transfer of wild type genes and small interferi...

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Bibliographic Details
Main Authors: Lingyan Wang, J. Beth Kempton, John V. Brigande
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
gene therapy
congenital deafness
fetal gene transfer
transuterine microinjection
window of therapeutic efficacy
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2018.00300/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2018.00300/full

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