Research advances in microRNAs in regulating hepatitis C virus replication and antiviral therapy
Hepatitis C virus (HCV) infection is one of the most common causes of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. MicroRNAs (miRNAs), a class of small, non-coding RNA, are involved in a variety of physiological and pathological processes in human bodies. The mechanism by which...
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| Format: | Article |
| Language: | zho |
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Editorial Department of Journal of Clinical Hepatology
2015-05-01
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| Series: | Linchuang Gandanbing Zazhi |
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| Online Access: | http://www.lcgdbzz.org/qk_content.asp?id=6525&ClassID=4159524 |
| Summary: | Hepatitis C virus (HCV) infection is one of the most common causes of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. MicroRNAs (miRNAs), a class of small, non-coding RNA, are involved in a variety of physiological and pathological processes in human bodies. The mechanism by which miRNAs regulate HCV replication is described, and the effects of liver-specific microRNA-122 antagonists on hepatitis C antiviral therapy are discussed. Our study indicates that miRNAs play an important regulatory role in HCV expression. Targeting miRNAs may be a potential therapeutic approach for treating HCV infection, but further studies are still in need. |
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| ISSN: | 1001-5256 1001-5256 |