Valproate alters dopamine signaling in association with induction of Par-4 protein expression.

Valproate alters dopamine signaling in association with induction of Par-4 protein expression.

Chromatin remodeling through histone modifications has emerged as a key mechanism in the pathophysiology of psychiatric disorders. Valproate (VPA), a first-line medication for bipolar disorder, is known to have histone deacetylase (HDAC) inhibitor activity, but the relationship between its efficacy...

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Bibliographic Details
Main Authors: Saebom Lee, Jaehoon Jeong, Young-Un Park, Yongdo Kwak, Seol Ae Lee, Haeryun Lee, Hyeon Son, Sang Ki Park
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3454414?pdf=render

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