Tamoxifen and bone morphogenic protein-7 modulate fibrosis and inflammation in the peritoneal fibrosis model developed in uremic rats

Tamoxifen and bone morphogenic protein-7 modulate fibrosis and inflammation in the peritoneal fibrosis model developed in uremic rats

Abstract Background Peritoneal fibrosis (PF) represents a long-term complication of peritoneal dialysis (PD), affecting peritoneal membrane (PM) integrity and function. Understanding the mechanisms underlying PF development in an uremic environment aiming alternative therapeutic strategies for treat...

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Bibliographic Details
Main Authors: Filipe M. O. Silva, Elerson C. Costalonga, Cleonice Silva, Ana C. O. Carreira, Samirah A. Gomes, Mari C. Sogayar, Camilla Fanelli, Irene L. Noronha
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Molecular Medicine
Subjects:
Peritoneal fibrosis
Peritoneal inflammation
Tamoxifen
BMP7
TGF-ß
Smads
Online Access:http://link.springer.com/article/10.1186/s10020-019-0110-5

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