Synthesis and Antimicrobial Activities of 5-Arylidene-thiazolidine-2,4-dione Derivatives

Antibiotic resistance is considered one of the world's major public health concerns. The main cause of bacterial resistance is the improper and repeated use of antibiotics. To alleviate this problem, new chemical substances against microorganisms are being synthesized and tested. Thiazolidines...

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Main Authors:	Ivanildo Mangueira da Silva, João da Silva Filho, Priscila Brandão Gomes da Silva Santiago, Micalyne Soares do Egito, Carlos André de Souza, Frederico Leite Gouveia, Rafael Matos Ximenes, Kêsia Xisto da Fonseca Ribeiro de Sena, Antonio Rodolfo de Faria, Dalci José Brondani, Julianna Ferreira Cavalcanti de Albuquerque
Format:	Article
Language:	English
Published:	Hindawi Limited 2014-01-01
Series:	BioMed Research International
Online Access:	http://dx.doi.org/10.1155/2014/316082

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spelling	doaj-1d6787b18e9e4b08922283df82621c432020-11-24T23:40:45ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/316082316082Synthesis and Antimicrobial Activities of 5-Arylidene-thiazolidine-2,4-dione DerivativesIvanildo Mangueira da Silva0João da Silva Filho1Priscila Brandão Gomes da Silva Santiago2Micalyne Soares do Egito3Carlos André de Souza4Frederico Leite Gouveia5Rafael Matos Ximenes6Kêsia Xisto da Fonseca Ribeiro de Sena7Antonio Rodolfo de Faria8Dalci José Brondani9Julianna Ferreira Cavalcanti de Albuquerque10Department of Pharmacy, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilDepartment of Antibiotics, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilDepartment of Pharmacy, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilDepartment of Pharmacy, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilDepartment of Antibiotics, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilDepartment of Pharmacy, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilDepartment of Antibiotics, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilDepartment of Antibiotics, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilDepartment of Pharmacy, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilDepartment of Pharmacy, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilDepartment of Pharmacy, Federal University of Pernambuco, Avenida Professor Moraes Rego 1235, Cidade Universitária, 50670-901 Recife, PE, BrazilAntibiotic resistance is considered one of the world's major public health concerns. The main cause of bacterial resistance is the improper and repeated use of antibiotics. To alleviate this problem, new chemical substances against microorganisms are being synthesized and tested. Thiazolidines are compounds having many pharmacological activities including antimicrobial activities. For this purpose some thiazolidine derivatives substituted at position 5 in the thiazolidine nucleus were synthesized and tested against several microorganisms. Using a disc diffusion method, antimicrobial activity was verified against Gram-positive, Gram-negative, and alcohol acid resistant bacteria and yeast. The minimum inhibition concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined. All derivatives showed antimicrobial activity mainly against Gram-positive bacteria, with MIC values ranging from 2 to 16 µg/mL.http://dx.doi.org/10.1155/2014/316082
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ivanildo Mangueira da Silva João da Silva Filho Priscila Brandão Gomes da Silva Santiago Micalyne Soares do Egito Carlos André de Souza Frederico Leite Gouveia Rafael Matos Ximenes Kêsia Xisto da Fonseca Ribeiro de Sena Antonio Rodolfo de Faria Dalci José Brondani Julianna Ferreira Cavalcanti de Albuquerque
spellingShingle	Ivanildo Mangueira da Silva João da Silva Filho Priscila Brandão Gomes da Silva Santiago Micalyne Soares do Egito Carlos André de Souza Frederico Leite Gouveia Rafael Matos Ximenes Kêsia Xisto da Fonseca Ribeiro de Sena Antonio Rodolfo de Faria Dalci José Brondani Julianna Ferreira Cavalcanti de Albuquerque Synthesis and Antimicrobial Activities of 5-Arylidene-thiazolidine-2,4-dione Derivatives BioMed Research International
author_facet	Ivanildo Mangueira da Silva João da Silva Filho Priscila Brandão Gomes da Silva Santiago Micalyne Soares do Egito Carlos André de Souza Frederico Leite Gouveia Rafael Matos Ximenes Kêsia Xisto da Fonseca Ribeiro de Sena Antonio Rodolfo de Faria Dalci José Brondani Julianna Ferreira Cavalcanti de Albuquerque
author_sort	Ivanildo Mangueira da Silva
title	Synthesis and Antimicrobial Activities of 5-Arylidene-thiazolidine-2,4-dione Derivatives
title_short	Synthesis and Antimicrobial Activities of 5-Arylidene-thiazolidine-2,4-dione Derivatives
title_full	Synthesis and Antimicrobial Activities of 5-Arylidene-thiazolidine-2,4-dione Derivatives
title_fullStr	Synthesis and Antimicrobial Activities of 5-Arylidene-thiazolidine-2,4-dione Derivatives
title_full_unstemmed	Synthesis and Antimicrobial Activities of 5-Arylidene-thiazolidine-2,4-dione Derivatives
title_sort	synthesis and antimicrobial activities of 5-arylidene-thiazolidine-2,4-dione derivatives
publisher	Hindawi Limited
series	BioMed Research International
issn	2314-6133 2314-6141
publishDate	2014-01-01
description	Antibiotic resistance is considered one of the world's major public health concerns. The main cause of bacterial resistance is the improper and repeated use of antibiotics. To alleviate this problem, new chemical substances against microorganisms are being synthesized and tested. Thiazolidines are compounds having many pharmacological activities including antimicrobial activities. For this purpose some thiazolidine derivatives substituted at position 5 in the thiazolidine nucleus were synthesized and tested against several microorganisms. Using a disc diffusion method, antimicrobial activity was verified against Gram-positive, Gram-negative, and alcohol acid resistant bacteria and yeast. The minimum inhibition concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined. All derivatives showed antimicrobial activity mainly against Gram-positive bacteria, with MIC values ranging from 2 to 16 µg/mL.
url	http://dx.doi.org/10.1155/2014/316082
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Synthesis and Antimicrobial Activities of 5-Arylidene-thiazolidine-2,4-dione Derivatives

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