Transcriptional signatures underlying dynamic phenotypic switching and novel disease biomarkers in a linear cellular model of melanoma progression

Transcriptional signatures underlying dynamic phenotypic switching and novel disease biomarkers in a linear cellular model of melanoma progression

Despite advances in therapeutics, the progression of melanoma to metastasis still confers a poor outcome to patients. Nevertheless, there is a scarcity of biological models to understand cellular and molecular changes taking place along disease progression. Here, we characterized the transcriptome p...

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Bibliographic Details
Main Authors: Diogo de Oliveira Pessoa, Flávia Eichemberger Rius, Debora D'Angelo Papaiz, Ana Luísa Pedroso Ayub, Alice Santana Morais, Camila Ferreira de Souza, Vinicius Ferreira da Paixão, João Carlos Setubal, Julia Newton-Bishop, Jérémie Nsengimana, Hatylas Azevedo, Eduardo Moraes Reis, Miriam Galvonas Jasiulionis
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Melanoma
Malignancy
Metastasis
EMT
Phenotype switch
Prognosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558621000178

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