Acquired Immunity Is Not Essential for Radiation-Induced Heart Dysfunction but Exerts a Complex Impact on Injury

Acquired Immunity Is Not Essential for Radiation-Induced Heart Dysfunction but Exerts a Complex Impact on Injury

While radiation therapy (RT) can improve cancer outcomes, it can lead to radiation-induced heart dysfunction (RIHD) in patients with thoracic tumors. This study examines the role of adaptive immune cells in RIHD. In Salt-Sensitive (SS) rats, image-guided whole-heart RT increased cardiac T-cell infil...

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Bibliographic Details
Main Authors: Rachel A. Schlaak, Anne Frei, Brian L. Fish, Leanne Harmann, Tracy Gasperetti, Jamie L. Pipke, Yunguang Sun, Hallgeir Rui, Michael J. Flister, Benjamin N. Gantner, Carmen Bergom
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
radiation-induced heart disease
cardiac radiation
cardiotoxicity
immune-compromised
IL-2 receptor gamma knockout
lymphocytes
Online Access:https://www.mdpi.com/2072-6694/12/4/983

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