Increased complement activation 3 to 6 h after trauma is a predictor of prolonged mechanical ventilation and multiple organ dysfunction syndrome: a prospective observational study

Increased complement activation 3 to 6 h after trauma is a predictor of prolonged mechanical ventilation and multiple organ dysfunction syndrome: a prospective observational study

Abstract Background Complement activation is a central mechanism in systemic inflammation and remote organ dysfunction following major trauma. Data on temporal changes of complement activation early after injury is largely missing. We aimed to describe in detail the kinetics of complement activation...

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Bibliographic Details
Main Authors: Ingrid Nygren Rognes, Søren Erik Pischke, William Ottestad, Jo Røislien, Jens Petter Berg, Christina Johnson, Torsten Eken, Tom Eirik Mollnes
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Molecular Medicine
Subjects:
Wounds and injuries
Humans
Complement activation
Complement membrane attack complex
Systemic inflammatory response syndrome
Multiple organ failure
Online Access:https://doi.org/10.1186/s10020-021-00286-3

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