An efficiently cleaved HIV-1 clade C Env selectively binds to neutralizing antibodies.

An efficiently cleaved HIV-1 clade C Env selectively binds to neutralizing antibodies.

An ideal HIV-1 Env immunogen is expected to mimic the native trimeric conformation for inducing broadly neutralizing antibody responses. The native conformation is dependent on efficient cleavage of HIV-1 Env. The clade B isolate, JRFL Env is efficiently cleaved when expressed on the cell surface. H...

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Main Authors: Saikat Boliar, Supratik Das, Manish Bansal, Brihaspati N Shukla, Shilpa Patil, Tripti Shrivastava, Sweety Samal, Sandeep Goswami, C Richter King, Jayanta Bhattacharya, Bimal K Chakrabarti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4379091?pdf=render

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